185 of these mRNAs (60%) were altered in the opposite direction in adult vs P10 islets (false discovery rate≤0.1), in which miR-17-5p expression is decreased, and a further 64 mRNAs (21%) were altered in the opposite direction in adult vs P10 islets but did not reach statistical significance ( Supplementary Data 1 ).
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Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.
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