Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.

Arthritis Res Ther · 2015 · PMC4570588 · PMID 26370839

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Apremilast showed a trend to increase IL-6 in this murine cell line (from 811 ± 416 to 1,986 ± 881 pg/ml, P <0.05) and modestly diminished the LPS-mediated increase of IL-1α (from 149 ± 26 to 97 ± 35 pg/ml, P <0.05).

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