Two-way ANOVA revealed a significant main effect of both genotype ( P < 0.05) and interval ( P < 0.0001); post hoc multiple comparisons revealed significant differences between wild-type and TASTPM at both 25 and 50 ms interpulse intervals. The increase in paired-pulse ratio suggests a decreased probability of glutamate release in both pathways and, although the trend to a difference in input/output relationship did not reach statistical significance, this would be consistent with a decrease in activity in the CA3 region, which would likely result in a decrease in spontaneous activity in the CA1 region, as reported above.
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First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression.
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