Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data.

However, after adjusting for their day 7 lumefantrine concentrations, the risk of recrudescence appeared to increase with a decrease in the weight-for-age Z-score (WAZ), but this did not reach statistical significance (HR 1.26; 95 % CI 0.94 to 1.69; P = 0.12 per unit decrease, which corresponds to a doubling of the recrudescence risk (HR 2.01; 95 % CI 0.83 to 4.83) for a young child with a WAZ of −3, when compared to an adequately nourished child with a WAZ of 0).

also in 111,027 other papers