Lumefantrine and Desbutyl-Lumefantrine Population Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria on the Thailand-Myanmar Border.

The median (range; quantile range) individually predicted lumefantrine concentrations at day 7 and area under the concentration-time curve from zero to infinity (AUC 0–∞ ) in patients with recrudescent malaria on admission (431 [121 to 1,650; 303 to 545] ng/ml and 541 [167 to 1,330; 367 to 694] μg · h/ml) or novel malaria (439 [140 to 933; 307 to 528] ng/ml and 528 [244 to 892; 384 to 636] μg · h/ml) tended to be only slightly lower than in patients with admission primary new malaria infections (469 [158 to 1,210; 326 to 710] ng/ml and 595 [157 to 1,340; 474 to 804] μg · h/ml), but it did not reach statistical significance ( P ≥ 0.05; analysis of variance [ANOVA] and regression analysis on logarithmically transformed day 7 and AUC).

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