Linagliptin 5 mg also showed a trend of nonsignificance to improve indexes of β-cell function, including fasting insulin, disposition index (DI), and homeostasis model assessment (HOMA) of IR. 25 Linagliptin as add-on therapy to one oral antidiabetic drug A 52-week, multicenter, open-label study evaluates the efficacy of linagliptin 5 mg once daily as add-on therapy to one background oral antidiabetic drug (OAD), including biguanide, glinide, glitazone, sulphonylurea (SU), and α-glucosidase inhibitor (A-GI), in 618 Japanese patients with T2DM inadequately controlled.
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