Enhanced oxidative stress by alcohol use in HIV+ patients: possible involvement of cytochrome P450 2E1 and antioxidant enzymes.

However, our recent reports [ 19 , 20 ] from the same number of subjects for HIV+ Smokers (n = 4) suggested that 4 subjects were sufficient to obtain significant (p ≤ 0.05) and borderline significant (p ≤ 0.1) differences between these groups.

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Importantly, this observation was associated with a significant trend towards enhanced transcription of CYP2E1 (~eightfold) in monocytes collected from HIV-infected alcohol users as compared to HIV-uninfected alcohol users (Fig. 2 b; p ≤ 0.1).

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