Consistent with this finding, double labeling and confocal microscopy studies with the oligodendroglial marker p25 and α-syn showed that the total number of oligodendrocytes were not significantly decreased in the striatum, however the levels of α-syn per oligodendroglial cell showed a trend to reduction between animals treated with LV-Control and LV- NR-R80Q-apoB, although this reduction was not statistically significant (Additional file 4 : Figure S4A, B).
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A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.
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