A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

PLoS Genet · 2015 · PMC4583245 · PMID 26407342

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.8900

boldest claim

The sentences

highly significantp = 1.32E-09actually significant

When analysed within the largest of our cohorts (YFS) the minor allelic effect size of rs113288603 increased from non-significant ( beta = 0.05, p = 0.522) to highly significant ( beta = -0.47, p = 1.32E-09) when rs56113850 was added to the model; when an interaction term (rs56113850*rs113288603) was also added to the model the effect size further increased ( beta = -0.62, p = 1.32E-03).

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showed a trendp = 0.89not close (p > 0.1)

Similarly, the major allele of CYP2A6*2 showed a trend of association with increased likelihood of being a former smoker (OR = 1.03, 95% CI 0.72–1.47, p = 0.89), although the results were not statistically significant.

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