FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk.

When gender was accounted for, amygdala reactivity was further modulated by age, such that older participants showed a trend towards lower amygdala reactivity (left hemisphere: b = −0.087, p = 0.096; right hemisphere: b = −0.090, p = 0.085).

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Here, using a cohort spanning the entire adult age range (16–96 years old), we extend these prior findings by reporting a robust and highly significant age-associate decrease in FREM3 expression in Brodmann areas 11 and 47—regions broadly overlapping with the orbitofrontal cortex (OFC) as well as the ventrolateral prefrontal cortex (vlPFC), both of which have previously been implicated in depression pathophysiology and risk (Rogers et al., 2004 ; Stuhrmann et al., 2011 ).

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