Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.

In the largest dataset ( GSE15222 ), we observed nominally significant differences in SNAP25 expression between females and males among AD patients but not among controls.

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Specifically, the female APOE+ cohort contained only five controls, which may explain why SNPs calculated to be significant in female APOE4+ patients in the other two data sets did not achieve significance in this subset.

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This difference was highly significant, with hypergeometric p-value 1.71 × 10 −4 .

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