We observed similar results when performing the enrichment analysis for the Segway segmentation track of GM12878 ( S4 Table ): strong enhancers were the most enriched (p < 0.0001); weak enhancers and active promoters did not achieve significance at the Bonferoni threshold (p = 0.0031 and p = 0.0419, respectively).
This hypothesis is further supported as a hematopoietic progenitor cell line, CD34+ Mobilized cells, was approaching significance in the DNase hypersensitivity enrichment analysis (p = 0.016).
Similarly, tissue-specific enhancer enrichment were also observed in the Roadmap Epigenomics data while the enrichment calculations for the transcription start site segmentation failed to reach significance ( S8 and S9 Tables).