A non-synonymous SNP, rs1799983, in NOS3 previously associated with cardiovascular phenotypes 25 is in weak LD with rs3918226 but did not achieve significance in an additive or joint association analysis.
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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
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The sentences
Of 48 previously reported loci at genome-wide levels of significance, 47 showed nominally significant associations ( Supplementary Table 2 ).