New genes drive the evolution of gene interaction networks in the human and mouse genomes.

Genome Biol · 2015 · PMC4590697 · PMID 26424194

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a clear trendno p-value reported

Together with aforementioned observations from the network topology, our analysis demonstrated a clear trend that human new genes gradually evolve to be topologically central and functionally essential, and acquire the capability to reshape the GGI networks.

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