The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.
The “AC” haplotype of the rs1046320 and rs9457 SNPs showed a highly significant association with the disease, on the other hand odds ratio was the lowest in case of this combination, and it is also remarkable that these two polymorphisms are in linkage disequilibrium with each other, which can also contribute to the observed low statistical p value of the χ 2 -probe.