<i>S</i>-Nitroso-<i>N</i>-acetylpenicillamine (SNAP) Impregnated Silicone Foley Catheters: A Potential Biomaterial/Device To Prevent Catheter-Associated Urinary Tract Infections.

3 − 5 Because of the high incidence and potential clinical relevance of these infections, the cost of medical intervention for CAUTIs is quite significant, with $450 M spent annually in the United States alone. 6 It is documented that microbial biofilms play a significant role in the pathogenesis of CAUTIs. 7 After the initial colonization of the abiotic surfaces, uropathogens form hydrated matrices of extracellular polymeric substances, dubbed as biofilms.

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