TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.

For instance, although the majority of studies have reported that the rs3775290 variant T allele was associated with an increased cancer risk (odds ratio [OR] > 1), four studies testing this conclusion did not reach statistical significance ( P > 0.05) [ 5 – 8 ] and only one additional study produced significant results ( P < 0.05) [ 9 ].

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