Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status – The HUNT Study.

PLoS One · 2015 · PMC4596824 · PMID 26445370

Europe PMC DOI

hedged sentences

0.0004

closest p · 0.0× alpha

0.0004

boldest claim

The sentences

highly significantP = 3.9x10 -4actually significant

The DRD2 (Dopamine receptor D2)-variant (rs6277) was highly significant where the C-allele displayed a protective effect towards overweight development (OR: 0.79, 95% CI: 0.69–0.90, P = 3.9x10 -4 , adj.

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nominally significantno p-value reported

The rs560887 ( G6PC2 ) was nominally significant in the combined sample and the rs533123 ( OPRD1 ), rs1049353 ( CNR1 , cannabinoid receptor 1) and rs10242595 ( IL6 , interleukin 6) showed associations in males (significant sex interaction identified for IL6 and nearly for CNR1 (P = 0.06)).

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