KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion.

PLoS One · 2015 · PMC4596849 · PMID 26444014

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Tolbutamide (0.5 mM) showed a trend to decrease both ATP and ADP (2.5 ± 0.1, n = 6, vs. 2.95 ± 0.3, n = 5, N.S. and 1.9 ± 0.1, n = 3 vs. 2.4 ± 0.3 pmol/islet, n = 3; N.S., respectively) in islets incubated at 5 mM glucose without modifying the ATP/ADP ratio (1.3 ± 0.07, n = 6, vs. 1.3 ± 0.04, n = 3; N.S.).

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