Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.

Arthritis Res Ther · 2015 · PMC4599327 · PMID 26449617

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showed a trendno p-value reported

Clinical effect based on physician disease assessment was less striking but generally showed a trend for improvement compared with placebo.

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