Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.

A significant trend in contemporary vaccinology is the design of highly effective subunit vaccines, and the majority of modern subunit vaccines that utilize highly purified, recombinantly expressed protein immunogens are reliant on vaccine adjuvants 2 , 3 (substances that enhance immune responses) to provide the initial, innate immune-activating signals that determine the specificity, magnitude, quality, and durability of downstream adaptive immune responses.

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