Although not differing significantly, the combination of COT plus UDCA showed a trend in reducing the risk of MOLT when compared with OBS (HR 2.05, 95% CI 0.50–8.93), monotherapy with UDCA (HR 2.63, 95% CI 0.72–10.75), COC plus UDCA (HR 2.55, 95% CI 0.44–15.03), MTX plus UDCA (HR 3.58, 95% CI 0.61–21.96), or BEF plus UDCA (HR 3.48, 95% CI 0.21–56.93).
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Network meta-analysis of randomized controlled trials: efficacy and safety of UDCA-based therapies in primary biliary cirrhosis.
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