highly significantP = 0.003
A highly significant association was observed between MV miR-21 levels and the anatomic location of the tumor ( P = 0.003), whereas the association with PV miR-21 levels was less significant ( P = 0.01) (Table 1 , Figure 1 C). miR-21 Expression and Metastases Of the 13 patients who developed metastases during the course of the disease, 8 had metastases in areas drained by the MV of the colon: 4 peritoneal metastases, 2 liver metastases, and 2 anastomotic.