Exposure of drugs for hypertension, diabetes, and autoimmune disease during pregnancy and perinatal outcomes: an investigation of the regulator in Japan.

For oral antidiabetics (Figure 2 B), the OR of fetal and neonatal death showed an increasing trend in the exposed group (OR, 4.86; 95% CI, 0.81–29.2).

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However, regardless of exposure to oral antidiabetics, the OR of fetal and neonatal death showed a decreasing trend in mothers with diabetes (OR, 0.49; 95% CI, 0.17–1.36).

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It should be noted that autoimmune disease itself was associated with an increased OR of malformation (OR, 6.95; 95% CI, 4.10–11.8); however, this association showed a trend opposite to that for exposure to corticosteroids and other immunosuppressants.

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