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Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.

J Am Heart Assoc · 2015 · PMC4608093 · PMID 26199228

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Although the increase in ROS production did not reach statistical significance when applying the paired t test, it was highly reproducible under different conditions tested.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.