High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancer.

Clin Epigenetics · 2015 · PMC4608326 · PMID 26478752

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantp < 0.001actually significant

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

Results We observed a borderline significant ( p = 0.06) reduction in 5hmC levels in PC compared to NM tissue samples, which was explained by a highly significant ( p < 0.001) loss of 5hmC in ERG− PCs.

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a borderline significant trendp = 0.06so close (0.05 < p ≤ 0.1)

Strong 5hmC staining was also significantly associated with advanced pT stage (pT3-4) in ERG− ( p = 0.001, chi 2 test; Additional file 2 : Figure S2), but not in ERG+ PCs, where instead a borderline significant trend towards reduced 5hmC staining in pT3-4 stage tumors was seen ( p = 0.06, chi 2 test; Additional file 3 : Figure S3).

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