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DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies.

Clin Epigenetics · 2015 · PMC4609112 · PMID 26478754

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a clear trendno p-value reported
presented that this gene was the only one showing a clear trend of increased gene expression in smokers compared to non-smokers with a prominent negative correlation between gene expression and methylation [ 20 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.