Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved.

Biosci Rep · 2015 · PMC4613684 · PMID 26182381

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Echocardiography With regard to EF and FS, both showed a trend toward gradual decline in the diabetic rats over the 12 weeks, with significant reductions ( P < 0.05) after diabetes was induced and significant increase( P < 0.05) in Fgl2–RNAi gene silencing group compared with diabetes group (DM), diabetic empty vector group (DM-GFP; Table 2 ).

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