Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Biosci Rep · 2015 · PMC4613725 · PMID 26330615

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failed to reach statistical significanceno p-value reported

Both TRPM8 R475C and K423N appeared to be marginally more sensitive to the antagonist AMTB compared with non-mutated TRPM8, with K423N apparently more sensitive to antagonist than R475C, although differences failed to reach statistical significance (see bar graphs in Figures 1 b and 1 c).

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