Recently, CXCR4, the receptor for CXCL12, was shown to be important for mammary progenitor cell fate ( Shiah et al., 2015 ) and we found its expression to be also decreased in the Rank -deficient Sca1 − luminal progenitor population, although this effect did not reach statistical significance ( Figure S2 C).
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RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.
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