Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas.

78 (22%) out of 350 cases showed positive ANO1 expression and a highly significant correlation was found when comparing ANO1 immunostaining detected with both antibodies (Spearman’s rho 0.917, P < 0.001).

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Multiple decrement Kaplan-Meier demonstrated that ANO1 expression is associated with increased disease-specific (DSS) and overall (OS) survival in the total cohort of 357 patients, although the differences did not reach statistical significance ( Table 2 ).

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