HIV-1 Infection Accelerates Age According to the Epigenetic Clock.

J Infect Dis · 2015 · PMC4621253 · PMID 25969563

Europe PMC DOI

hedged sentence

0.0330

closest p · 0.7× alpha

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only marginally significantP = .033actually significant

A multivariate regression analysis suggested that cases with detectable viral load (ie, >35 copies/mL) had a DNA methylation age that was on average 3.6 years greater than that of adult male cases with a nondetectable viral load, but the association was only marginally significant ( P = .033) and requires further validation studies.

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