Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.

Additionally, we found that the induction of cell death was partially sensitive to caspase inhibition, as treatment of cells with the pan-caspase inhibitor zVAD-fmk was sufficient to block Unc93b induced morphological changes associated with cell death and caused a mild reduction in PI- and Annexin V-positive cells that did not reach statistical significance ( Fig 1F, 1G and 1H ).

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