Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.

Mol Med Rep · 2015 · PMC4626146 · PMID 26323321

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a significant trendno p-value reported

The growth curve obtained from the rat weights demonstrated that the APS-G group exhibited a significant trend towards weight loss, as compared with the CUGFR group.

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may be significantno p-value reported

Therefore, the present study hypothesized that the SIRT1-PGC-1α/PPARα-FGF21 signaling pathway may be significant in the pathogenesis of hepatic insulin resistance under catch-up growth.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.