Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients.

Densitometric analysis of Western immunoblots demonstrated that Tacr-1 protein levels were increased in human mesenteric preadipocytes isolated from Crohn’s disease patients, and there was a strong trend for increase in UC patient preadipocytes ( Figure 2 D , P < .05, n = 4).

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