Traumatic Brain Injury by a Closed Head Injury Device Induces Cerebral Blood Flow Changes and Microhemorrhages.

from 4 h to 8 h after trauma, but not during the initial 3-h period post-trauma induced by dropping a 450 g weight from 1 m which induces a mild injury.[ 18 ] In a separate study, Petrov et al., using a similar trauma model, reported a decrease in the cerebral blood flow by 2–3 h after trauma that showed a trend toward normalization by 4 h post-trauma.[ 19 ] Shen et al., using magnetic resonance imaging based perfusion imaging in a similar trauma model, reported reduced hippocampal cerebral blood flow at 4 h (8-14%), 24 h (8%), and 48 h post-trauma (18%), compared to their pre-injury levels.

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