A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.

Likewise, at least comparable fold improvements are seen in PFRM over BCRAT lifetime risk estimates between 2.6 and 2.8 at risk threshold of ≥ 20 and 25%, respectively, and these are also highly significant (p < 0.0001).

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Improvements in AUC ranging from 0.06 to 0.14 (p = 0.02 to 0.0003) were observed for all but one 5-year age group (age 50–54), where the difference of 0.05 did not reach statistical significance.

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