5 , 6 A double-blind, double-dummy, crossover, randomized study carried out by Cazzola et al 7 to explore the acute effects of adding salmeterol to tiotropium in patients with stable COPD showed that the addition of salmeterol to tiotropium elicited a significantly faster onset of action and showed a trend for a greater maximum bronchodilation than single drugs alone.
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Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease.
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