borderline significancep = 0.01
Thus, to summarize, the most robust results overall were for mQTL associated with SCDA metabolite levels (factor 3) including an mQTL composed of USP3 (rs10450989) and HERC1 (rs2228513); and a locus composed of STON2 (rs12589750) and SEL1L (rs3853422), with loci meeting genomewide significance in the discovery cohort (p≤10 −6 ), strong significance in the validation cohort (p = 2.4x10 -3 –7.7x10 -7 , except rs3853422 which only showed borderline significance [p = 0.01]), and stronger association in the meta-analyses (p = 1.6x10 -6 –7.2x10 -12 ).