In the third International Stroke Trial (IST-3) where 53% of 3,035 patients enrolled were aged > 80 years, the benefit of TPA was greater in patients aged > 80 years than in those ≤ 80 years, but the result did not reach statistical significance [ 12 ].
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Intravenous Tissue Plasminogen Activator Improves the Outcome in Very Elderly Korean Patients with Acute Ischemic Stroke.
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