There was also an observed trend of decreased incidence of clinical worsening; however, at no point did this trend become significant in either age group alone.
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Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review.
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The sentences
Treatment-naïve patients receiving tadalafil 20 mg and bosentan background patients experienced an increase in placebo-adjusted 6MWD that failed to reach statistical significance.