Confirming previous results, numbers of circulating naïve B cells were lower in the aged [ 25 ] while numbers of some of the other subsets only showed a trend towards an age-related decline.
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BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine.
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The sentences
There was a trend towards increased numbers of transitional B cells, which form a link between immature B cells in bone marrow and mature naïve B cells in the periphery in younger individuals; this failed to reach significance.