Barely Significant
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Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

J Exp Med · 2015 · PMC4647268 · PMID 26481686

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A mild reduction in Aβ42 production rate was observed in the E120G-, P264L-, and R278I-PSEN1 brain samples, but the differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.