However, five other studies not included in the review failed to reach significance, suggesting that the prognostic value of p53 may not be as obvious as the meta-analysed results suggest ( Duhaylongsod et al , 1995 ; Coggi et al , 1997 ; Hardwick et al , 1997 ; Langer et al , 2006 ; Falkenback et al , 2008 ).
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Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma.
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The sentences
Lgr5 failed to reach statistical significance as a prognostic marker.