Postmenopausal mammographic breast density and subsequent breast cancer risk according to selected tissue markers.

In the analysis by AR, CK5/6, and EGFR, the differences in subset-specific associations were significant for CK5/6 ( P heterogeneity =0.002) and EGFR ( P heterogeneity =0.001) and were marginally significant for AR ( P heterogeneity =0.07).

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Results: The association of percent density with breast cancer risk appeared to be stronger in ER− as compared with ER+ tumours, but the difference did not reach statistical significance (density ⩾50% vs <10% odds ratio (OR)=3.06, 95% confidence interval (CI) 2.17–4.32 for ER+ OR=4.61, 95% CI 2.36–9.03 for ER−, P heterogeneity =0.08).

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