BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures.

As depicted in figure 2 , the overrepresentation of children of Sub-Saharan African descent across the higher quintiles of the BMD-GS was highly significant in both studies (Generation R: P = 2.7 × 10 − 71 and BMDCS, P = 2.3 × 10 − 70 ).

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In children of predominantly East Asian ancestry (with the lowest sample size) the effect of the score on BMD did not reach statistical significance in either study.

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