CoCStom trial: study protocol for a randomised trial comparing completeness of adjuvant chemotherapy after early versus late diverting stoma closure in low anterior resection for rectal cancer.

The only larger, albeit retrospective, study investigating stoma related complications and postoperative morbidity in 120 patients with colorectal carcinoma undergoing colorectal resections in regard to adjuvant chemotherapy showed a trend toward fewer complications (12.5 %) if stoma closure was performed early (i.e. before starting adjuvant chemotherapy) rather then during (42.9 %) or after (21.2 %) chemotherapy [ 7 ].

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