In fact, quite significant differences in the orientation of the first α-helix of RGS14' GoLoco could be seen between the two structures [ 9 , 10 ] explaining the different rotation of the modelled α-helix of Pins' GoLoco1 motif ( Figures 3 A and 3 B).
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Mode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides.
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