An increasing resistance trend over time was also observed, however this increase did not reach statistical significance because of reduced statistical power.
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Ciprofloxacin resistance in community- and hospital-acquired Escherichia coli urinary tract infections: a systematic review and meta-analysis of observational studies.
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coli specimens in Switzerland, found an increasing trend in resistance to ciprofloxacin, from 1.8 to 15.9 % [ 6 ].