Barely Significant
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Ciprofloxacin resistance in community- and hospital-acquired Escherichia coli urinary tract infections: a systematic review and meta-analysis of observational studies.

BMC Infect Dis · 2015 · PMC4660780 · PMID 26607324

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An increasing resistance trend over time was also observed, however this increase did not reach statistical significance because of reduced statistical power.

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an increasing trendno p-value reported
coli specimens in Switzerland, found an increasing trend in resistance to ciprofloxacin, from 1.8 to 15.9 % [ 6 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.