Pit- and trench-forming osteoclasts: a distinction that matters.

The expression level of CatK proved to be highly variable (max/min = 146:1) for both genders, but a clear trend ( P = 0.07) also suggests that there on average is a higher expression of CatK in OCs generated from male donors than in those generated from female donors ( Figure 4e ).

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Notably, the difference between the two groups remains highly significant when subdividing them according to the gender of the donors ( Supplementary Figure S1 ).

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